Positive regulation of T-helper 2 cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of T-helper 2 cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SKAP2, WAS, and MYO1F, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T-helper 2 cell differentiation activity versus SKAP2 in OV (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SKAP2 →	+0.729	+0.058	<.001	<.001	3	9
UCEC	WAS →	+0.685	+0.071	<.001	.007	3	9
GBM	MYO1F →	+0.640	+0.085	<.001	<.001	3	9
GBM	ARHGAP45 →	+0.576	+0.077	<.001	<.001	3	9
GBM	PTPRC →	+0.759	+0.093	<.001	<.001	3	9
GBM	C1QA →	+0.711	+0.078	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045630 vs SKAP2 — OV

Explore this scatter interactively →