Positive regulation of T-helper 2 cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of T-helper 2 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS24P7, DPF2, and ZNF619, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T-helper 2 cell differentiation activity versus RPS24P7 in BRCA (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPS24P7 →	-1.242	-0.258	<.001	.002	3	4
OV	DPF2 →	+0.529	+0.619	.005	.007	3	3
OV	ZNF619 →	+0.701	+0.763	.004	.007	3	3
LUAD	KLHL26 →	+0.241	+0.431	.002	<.001	3	3
BRCA	NR3C1 →	+0.495	+0.232	.004	.003	3	3
BRCA	MLPH →	+1.783	+0.271	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045630 vs RPS24P7 — BRCA

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