Positive regulation of T-helper 2 cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of T-helper 2 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBASH3B, HDAC9, and PLAUR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBASH3B grouped by Positive regulation of T-helper 2 cell differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	UBASH3B →	-1.612	-0.698	<.001	.001	3	5
BREAST	HDAC9 →	-1.517	-0.924	.001	<.001	3	5
SOFT_TISSUE	PLAUR →	-2.787	-1.269	<.001	.006	3	4
SKIN	SSPN →	-1.354	-0.921	<.001	<.001	3	4
BREAST	PRODH →	+2.105	+0.773	.003	<.001	3	4
BONE	RGCC →	-3.647	-1.677	.003	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBASH3B by Positive regulation of T-helper 2 cell differentiation activity — BREAST

Explore this box plot interactively →