Positive regulation of T-helper 2 cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of T-helper 2 cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNS3, H3-5, and SELE, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TNS3 grouped by Positive regulation of T-helper 2 cell differentiation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TNS3 →	+0.190	+0.186	<.001	<.001	3	4
LUNG_SCLC	H3-5 →	-0.205	-1.291	<.001	.005	3	4
LUNG_SCLC	SELE →	-0.215	-1.115	.003	.004	3	3
BONE	CACNA1E →	-0.157	-1.722	.002	<.001	3	3
CNS	SEC63 →	+0.160	+1.386	.007	.001	3	3
BLOOD_Myeloma	REXO1 →	-0.326	-0.386	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TNS3 by Positive regulation of T-helper 2 cell differentiation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →