Positive regulation of T-helper 1 cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of T-helper 1 cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANK2, S100B, and SEPTIN1_S315, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T-helper 1 cell differentiation activity versus ANK2 in BRCA (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ANK2 →	+0.386	+0.047	<.001	<.001	3	8
BRCA	S100B →	+1.188	+0.073	<.001	<.001	3	7
LSCC	SEPTIN1_S315 →	+0.791	+0.068	<.001	<.001	3	7
COAD	SH3BGRL →	+0.492	+0.062	.002	<.001	3	7
HNSC	CAMSAP3_S334 →	-0.650	-0.081	<.001	<.001	3	7
HNSC	SEPTIN1 →	+0.679	+0.086	<.001	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045627 vs ANK2 — BRCA

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