Positive regulation of T-helper 1 cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of T-helper 1 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCKAP1L, RIPK2, and LILRB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T-helper 1 cell differentiation activity versus NCKAP1L in LSCC (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NCKAP1L →	+0.596	+0.514	.006	.004	3	5
LUAD	RIPK2 →	+0.602	+0.833	<.001	<.001	2	6
CCRCC	LILRB1 →	+0.448	+0.553	.001	.003	3	5
CCRCC	TLR6 →	+0.404	+0.464	.001	.001	3	5
GBM	TSPYL4 →	-0.428	-0.628	<.001	<.001	3	5
CCRCC	NAIP →	+0.347	+0.470	.002	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045627 vs NCKAP1L — LSCC

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