Positive regulation of T-helper 1 cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of T-helper 1 cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RIPK2_S363, RIPK2, and RIPK2_S176, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T-helper 1 cell differentiation activity versus RIPK2_S363 in CCRCC (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RIPK2_S363 →	+0.708	+0.676	<.001	<.001	3	7
BRCA	RIPK2 →	+0.479	+0.506	<.001	<.001	3	5
OV	RIPK2_S176 →	+1.903	+0.960	<.001	<.001	3	4
BRCA	RIPK2_S178 →	+0.952	+0.634	<.001	<.001	3	4
PDAC	RIPK2_S393 →	+0.586	+0.827	<.001	<.001	3	4
CCRCC	ACTR2 →	+0.144	+0.680	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045627 vs RIPK2_S363 — CCRCC

Explore this scatter interactively →