Positive regulation of T-helper 1 cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of T-helper 1 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED11, METTL7A, and SLC16A9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MED11 grouped by Positive regulation of T-helper 1 cell differentiation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MED11 →	-0.549	-1.042	.003	.004	3	4
CNS	METTL7A →	-1.890	-1.002	.002	.003	2	5
KIDNEY	SLC16A9 →	-1.142	-0.953	.003	<.001	3	4
OVARY	SMIM22 →	-3.145	-1.238	.001	<.001	3	4
CNS	LGALS3 →	-2.082	-1.139	.009	<.001	3	3
OVARY	HNRNPA1 →	+0.764	+1.138	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MED11 by Positive regulation of T-helper 1 cell differentiation activity — CNS

Explore this box plot interactively →