Positive regulation of T-helper 1 cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of T-helper 1 cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX6A1, IL15, and PCGF5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COX6A1 grouped by Positive regulation of T-helper 1 cell differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	COX6A1 →	-0.179	-0.641	<.001	.005	3	5
KIDNEY	IL15 →	-0.148	-0.073	.004	.005	3	4
BREAST	PCGF5 →	-0.135	-0.709	.005	.008	2	5
BLOOD_Myeloma	RASGRP2 →	-0.177	-1.321	<.001	.007	3	4
LUNG_NSCLC_LUAD	POLI →	+0.247	+0.094	<.001	.005	2	4
LUNG_SCLC	SARAF →	+0.296	+1.221	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COX6A1 by Positive regulation of T-helper 1 cell differentiation activity — BREAST

Explore this box plot interactively →