Regulation of T-helper 1 cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of T-helper 1 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF629, ATG2B, and RIPK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T-helper 1 cell differentiation activity versus ZNF629 in LUAD (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ZNF629 →	-0.382	-0.452	.003	.009	3	5
BRCA	ATG2B →	-0.487	-0.569	.001	.001	3	5
LUAD	RIPK2 →	+0.605	+0.625	<.001	<.001	2	5
HNSC	DNAJC27 →	-0.337	-0.247	.008	.009	3	4
GBM	HOXA7 →	-0.615	-0.543	.002	.005	3	4
CCRCC	NCKAP1L →	+0.484	+0.563	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045625 vs ZNF629 — LUAD

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