Regulation of T-helper 1 cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of T-helper 1 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA2, ZBTB26, and LSG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITGA2 grouped by Regulation of T-helper 1 cell differentiation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ITGA2 →	-2.718	-1.325	.005	.004	3	5
PANCREAS	ZBTB26 →	-0.585	-1.110	.005	.001	3	4
OVARY	LSG1 →	-0.851	-0.788	.007	.005	3	4
BLOOD_Lymphoma	RAD50 →	-1.293	-2.029	.009	.001	2	5
OVARY	ZCCHC7 →	-0.682	-0.923	.001	.003	2	4
BREAST	STK17A →	-0.851	-0.706	.006	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITGA2 by Regulation of T-helper 1 cell differentiation activity — STOMACH

Explore this box plot interactively →