Regulation of T-helper 1 cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of T-helper 1 cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLI, NDUFAF5, and PRKCZ, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLI grouped by Regulation of T-helper 1 cell differentiation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	POLI →	+0.229	+1.970	.003	<.001	3	4
SOFT_TISSUE	NDUFAF5 →	-0.238	-0.324	<.001	.001	3	4
SOFT_TISSUE	PRKCZ →	-0.250	-0.308	.002	<.001	2	5
LIVER	IBTK →	-0.221	-1.082	.001	.004	3	4
BREAST	ECHS1 →	-0.114	-1.198	.001	<.001	3	4
BREAST	ZBTB7B →	-0.131	-0.679	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLI by Regulation of T-helper 1 cell differentiation activity — LUNG_SCLC

Explore this box plot interactively →