Positive regulation of T-helper cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of T-helper cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYNDIG1L, PATZ1, and RIPK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T-helper cell differentiation activity versus SYNDIG1L in LUAD (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SYNDIG1L →	-0.440	-0.248	.002	.008	3	4
GBM	PATZ1 →	-0.659	-0.787	<.001	<.001	3	4
GBM	RIPK2 →	+0.629	+0.829	<.001	<.001	3	4
CCRCC	PAEP →	+1.435	+0.815	<.001	<.001	3	4
HNSC	DSC2 →	+1.003	+0.483	.001	<.001	3	4
GBM	FXYD6 →	-1.211	-1.040	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045624 vs SYNDIG1L — LUAD

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