Negative regulation of T-helper cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of T-helper cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MRC2, PPP1R18_S224, and NRP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T-helper cell differentiation activity versus MRC2 in LSCC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MRC2 →	+0.613	+0.065	<.001	<.001	3	8
LSCC	PPP1R18_S224 →	+0.555	+0.051	<.001	.002	3	8
GBM	NRP2 →	+0.797	+0.117	<.001	<.001	3	7
HNSC	AFAP1_S548 →	+0.642	+0.071	<.001	<.001	3	7
GBM	CNN2 →	+0.883	+0.103	<.001	<.001	3	7
BRCA	DOCK11 →	+0.290	+0.044	.002	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045623 vs MRC2 — LSCC

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