Negative regulation of T-helper cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of T-helper cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBED3, PANK1, and SH2B1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T-helper cell differentiation activity versus ZBED3 in BLOOD_Lymphoma (Pearson r = -0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZBED3 →	-2.242	-0.550	.001	.009	3	3
BLOOD_Lymphoma	PANK1 →	-1.263	-0.685	.008	.003	3	3
SKIN	SH2B1 →	-0.643	-0.189	.001	.002	3	3
SKIN	PDXP →	-1.196	-0.249	.002	.005	3	3
BLOOD_Leukemia	MSL1 →	-0.553	-1.749	.001	<.001	3	2
BLOOD_Leukemia	GRAPL →	-1.515	-1.445	.009	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045623 vs ZBED3 — BLOOD_Lymphoma

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