Regulation of T-helper cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of T-helper cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, SAMSN1_S23, and TBC1D2B, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T-helper cell differentiation activity versus RCSD1 in HNSC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RCSD1 →	+0.706	+0.062	<.001	<.001	3	10
LSCC	SAMSN1_S23 →	+0.747	+0.048	<.001	<.001	3	10
GBM	TBC1D2B →	+0.373	+0.092	<.001	<.001	3	10
GBM	CORO1A →	+0.678	+0.133	<.001	<.001	3	10
GBM	AIF1 →	+0.871	+0.116	<.001	<.001	3	10
GBM	FERMT3 →	+0.759	+0.116	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045622 vs RCSD1 — HNSC

Explore this scatter interactively →