Regulation of T-helper cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of T-helper cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FTH1P2, DLG2, and TUB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T-helper cell differentiation activity versus FTH1P2 in BRCA (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FTH1P2 →	+1.403	+0.718	<.001	<.001	3	4
GBM	DLG2 →	-0.720	-0.492	<.001	<.001	3	3
GBM	TUB →	-0.816	-0.407	<.001	.002	3	3
LUAD	REL →	+0.511	+0.383	.001	.007	3	3
GBM	GCAT →	-0.598	-0.452	<.001	.002	3	3
UCEC	VRK1 →	-0.604	-0.382	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045622 vs FTH1P2 — BRCA

Explore this scatter interactively →