Positive regulation of lymphocyte differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of lymphocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC85B, SLC10A3, and DRAP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC85B grouped by Positive regulation of lymphocyte differentiation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CCDC85B →	-1.312	-0.220	<.001	<.001	3	6
SOFT_TISSUE	SLC10A3 →	-1.105	-0.286	.002	.008	2	6
LUNG_NSCLC_LUSC	DRAP1 →	-1.518	-0.247	.001	.002	3	5
CNS	TMEM255B →	-1.423	-0.196	.008	<.001	3	5
CNS	STOML1 →	-0.794	-0.185	.003	.003	3	5
LUNG_NSCLC_LUSC	TNIP2 →	-0.947	-0.219	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC85B by Positive regulation of lymphocyte differentiation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →