Negative regulation of lymphocyte differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of lymphocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOOK1, IGF1R, and THRB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lymphocyte differentiation activity versus HOOK1 in GBM (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HOOK1 →	-0.553	-0.571	<.001	<.001	3	4
BRCA	IGF1R →	-0.940	-0.580	<.001	<.001	3	4
BRCA	THRB →	-0.596	-0.625	.001	<.001	3	4
BRCA	AKR7A3 →	-1.131	-0.545	.004	.001	3	4
BRCA	HSPA8P15 →	-0.712	-0.556	<.001	.001	3	4
GBM	TEX29 →	-0.467	-0.908	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045620 vs HOOK1 — GBM

Explore this scatter interactively →