Negative regulation of lymphocyte differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of lymphocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPCAM, NFIC, and POLR1E, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lymphocyte differentiation activity versus EPCAM in URINARY_TRACT (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	EPCAM →	-5.555	-1.088	.008	.001	3	7
OVARY	NFIC →	+2.009	+0.411	<.001	.001	3	7
PANCREAS	POLR1E →	+1.260	+0.372	.003	.006	2	7
UPPER_AERODIGESTIVE_TRACT	CBFB →	+1.025	+0.610	.001	.001	3	6
LARGE_INTESTINE	PBK →	+1.073	+0.266	<.001	.003	3	6
UPPER_AERODIGESTIVE_TRACT	WDR76 →	+1.319	+0.496	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045620 vs EPCAM — URINARY_TRACT

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