Regulation of lymphocyte differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of lymphocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN5, TRABD2A, and PSMB8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lymphocyte differentiation activity versus TSPAN5 in SOFT_TISSUE (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TSPAN5 →	+3.051	+0.225	.002	<.001	3	5
BLOOD_Lymphoma	TRABD2A →	+1.586	+0.210	.004	.002	3	5
BLOOD_Lymphoma	PSMB8 →	+0.946	+0.220	.001	.001	3	5
SOFT_TISSUE	VPS37B →	+0.882	+0.278	.002	.003	3	5
BLOOD_Leukemia	PSME1 →	+0.583	+0.123	<.001	.001	3	4
STOMACH	PCED1B →	-2.008	-0.252	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045619 vs TSPAN5 — SOFT_TISSUE

Explore this scatter interactively →