Positive regulation of keratinocyte differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of keratinocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DHRS9, EVPL_S2025, and ARPC5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of keratinocyte differentiation activity versus DHRS9 in HNSC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DHRS9 →	+1.042	+0.057	.001	.005	3	4
UCEC	EVPL_S2025 →	+0.934	+0.100	<.001	<.001	3	4
BRCA	ARPC5 →	+0.235	+0.028	<.001	<.001	3	4
UCEC	SCEL →	+1.108	+0.062	<.001	.002	3	4
UCEC	SCEL_S68 →	+1.148	+0.060	<.001	<.001	3	4
UCEC	EVPL →	+0.649	+0.070	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045618 vs DHRS9 — HNSC

Explore this scatter interactively →