Positive regulation of keratinocyte differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of keratinocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIOX1, KIAA0513, and CCDC112, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of keratinocyte differentiation activity versus RIOX1 in OV (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RIOX1 →	+0.475	+0.377	.003	.001	3	4
GBM	KIAA0513 →	-0.765	-0.805	<.001	.002	3	4
OV	CCDC112 →	+0.394	+0.244	.008	.006	3	3
LSCC	CDC20 →	+0.705	+0.448	.002	.006	3	3
LSCC	CD93 →	-0.626	-0.384	<.001	.002	3	3
LSCC	DIPK2B →	-0.355	-0.283	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045618 vs RIOX1 — OV

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