Positive regulation of keratinocyte differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of keratinocyte differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DMP1, STRN4, and CAB39L, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DMP1 grouped by Positive regulation of keratinocyte differentiation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DMP1 →	+0.442	+0.276	.001	.004	3	9
BONE	STRN4 →	+0.563	+0.238	.007	.002	3	6
LUNG_NSCLC_LUSC	CAB39L →	+0.224	+0.206	.004	.001	3	5
BONE	CACNG1 →	+0.136	+0.237	.006	.006	3	4
BONE	VSX2 →	+0.530	+0.293	.008	<.001	3	4
BONE	SEC24D →	+0.187	+0.230	.009	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DMP1 by Positive regulation of keratinocyte differentiation activity — BONE

Explore this box plot interactively →