Positive regulation of keratinocyte differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of keratinocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMP3, PLBD2, and MBTD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of keratinocyte differentiation activity versus EMP3 in LUNG_NSCLC_LUSC (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	EMP3 →	-5.429	-0.424	.003	.002	3	7
OESOPHAGUS	PLBD2 →	-0.805	-0.258	.004	.005	3	6
BLOOD_Lymphoma	MBTD1 →	+0.942	+0.202	.001	.007	3	5
BLOOD_Lymphoma	LGALS1 →	-3.045	-0.173	.002	.001	3	5
BLOOD_Lymphoma	RASGEF1B →	+1.688	+0.197	.001	.001	3	5
BLOOD_Lymphoma	SYTL1 →	+2.368	+0.185	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045618 vs EMP3 — LUNG_NSCLC_LUSC

Explore this scatter interactively →