Positive regulation of keratinocyte differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of keratinocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DSP, MACROH2A2, and DPM3, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of keratinocyte differentiation activity versus DSP in KIDNEY (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DSP →	+2.648	+0.419	<.001	<.001	3	14
BONE	MACROH2A2 →	+2.571	+0.408	<.001	<.001	3	14
SKIN	DPM3 →	-0.781	-0.140	<.001	.008	3	7
LUNG_NSCLC_LUSC	CHD4 →	+0.795	+0.282	.002	.003	3	6
SOFT_TISSUE	TGOLN2 →	-1.391	-0.288	.006	.008	2	7
OVARY	NUMA1 →	+0.794	+0.221	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045618 vs DSP — KIDNEY

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