Regulation of inner ear auditory receptor cell differentiation

pathway activity — cross-omics
GO:0045607Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of inner ear auditory receptor cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are QKI, SEC24A, and DOCK11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCAQKI →+0.363+0.073<.001<.00136
LSCCSEC24A →-0.384-0.105<.001<.00136
OVDOCK11 →-0.322-0.059.005.00236
LUADPHF10 →+0.247+0.073<.001<.00136
GBMCASP8 →-0.359-0.103<.001<.00135
PDACCOL4A2 →+0.210+0.040.005.00235
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration