Positive regulation of endothelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of endothelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM100, TRIM2, and PRKAR1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endothelial cell differentiation activity versus TMEM100 in OV (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TMEM100 →	+1.959	+0.180	.001	.001	3	5
LSCC	TRIM2 →	+0.579	+0.430	.008	.004	3	4
LUAD	PRKAR1A →	+0.349	+0.119	.004	.003	3	3
HNSC	PDE8B →	+0.404	+0.677	.001	.001	3	3
LUAD	SMAD9 →	+0.506	+0.106	.005	.002	3	3
GBM	ANKFN1 →	+1.011	+0.384	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045603 vs TMEM100 — OV

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