Positive regulation of endothelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of endothelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOCAD, PCCB, and PUS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FOCAD grouped by Positive regulation of endothelial cell differentiation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FOCAD →	+0.852	+1.069	<.001	<.001	3	5
LIVER	PCCB →	+0.755	+0.278	<.001	.003	3	4
SOFT_TISSUE	PUS1 →	+0.620	+0.244	.009	.001	2	4
LUNG_NSCLC_LUSC	BHLHE40 →	-0.941	-0.291	.001	.004	3	3
UPPER_AERODIGESTIVE_TRACT	FRMD4A →	+1.726	+0.867	.002	.006	2	4
UPPER_AERODIGESTIVE_TRACT	BAG4 →	+0.949	+1.062	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FOCAD by Positive regulation of endothelial cell differentiation activity — LARGE_INTESTINE

Explore this box plot interactively →