Negative regulation of endothelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of endothelial cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD93, CDH5, and HSPG2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of endothelial cell differentiation activity versus CD93 in BRCA (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD93 →	+0.667	+0.075	<.001	<.001	3	8
OV	CDH5 →	+0.394	+0.066	.001	<.001	3	8
UCEC	HSPG2 →	+0.461	+0.058	.005	.008	3	8
GBM	LAMA4 →	+0.682	+0.118	<.001	<.001	3	8
GBM	LAMB1 →	+0.588	+0.093	.002	.002	3	8
BRCA	RSU1 →	+0.464	+0.072	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045602 vs CD93 — BRCA

Explore this scatter interactively →