Negative regulation of endothelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of endothelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF586, PMS2, and E2F2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF586 grouped by Negative regulation of endothelial cell differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZNF586 →	+0.656	+0.696	.002	.008	3	4
OVARY	PMS2 →	+0.705	+1.020	<.001	.004	3	4
LUNG_NSCLC_LUSC	E2F2 →	+1.092	+1.462	.008	.001	3	4
LUNG_NSCLC_LUSC	BCL7A →	+1.055	+1.871	.008	<.001	3	4
LUNG_NSCLC_LUSC	HNRNPH1 →	+0.909	+1.526	.005	<.001	3	4
LUNG_NSCLC_LUSC	MSL1 →	+0.926	+1.607	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF586 by Negative regulation of endothelial cell differentiation activity — BREAST

Explore this box plot interactively →