Negative regulation of endothelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of endothelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C11orf98, GLIS3, and CHST10, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of endothelial cell differentiation activity versus C11orf98 in LUNG_NSCLC_LUAD (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C11orf98 →	+0.716	+0.238	<.001	.009	3	2
LARGE_INTESTINE	GLIS3 →	+1.880	+0.259	<.001	.003	3	2
LARGE_INTESTINE	CHST10 →	+0.114	+0.259	<.001	.003	3	2
LARGE_INTESTINE	DYNC2I1 →	+0.770	+0.254	.002	.004	3	2
LARGE_INTESTINE	DENND4C →	+1.409	+0.409	.005	.002	3	2
LARGE_INTESTINE	BRD3OS →	+0.553	+0.259	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045602 vs C11orf98 — LUNG_NSCLC_LUAD

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