Positive regulation of fat cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRP1, PIGH, and STRN3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fat cell differentiation activity versus RRP1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RRP1 →	-0.947	-0.172	<.001	.007	2	6
LUNG_SCLC	PIGH →	-0.730	-0.146	<.001	<.001	3	4
LUNG_NSCLC_LUSC	STRN3 →	-0.848	-0.169	.003	.001	3	4
URINARY_TRACT	PPP2R5C →	-0.657	-0.226	.003	.003	3	4
PANCREAS	IPO4 →	-1.188	-0.215	.001	.004	3	4
PANCREAS	PRRC2A →	-0.965	-0.115	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045600 vs RRP1 — UPPER_AERODIGESTIVE_TRACT

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