Positive regulation of fat cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of fat cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF5, RPS19, and FKBP3, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fat cell differentiation activity versus EIF5 in PANCREAS (Pearson r = -0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	EIF5 →	-1.935	-0.286	<.001	<.001	3	12
PANCREAS	RPS19 →	-1.337	-0.261	<.001	.001	3	8
PANCREAS	FKBP3 →	-1.736	-0.196	<.001	<.001	3	8
PANCREAS	DIAPH1 →	-1.059	-0.174	.003	.001	3	8
LUNG_NSCLC_LUSC	DNAJB1 →	-2.090	-0.167	.003	.002	3	8
LIVER	CAPRIN1 →	-1.625	-0.214	.007	.006	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045600 vs EIF5 — PANCREAS

Explore this scatter interactively →