Negative regulation of fat cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CERS5, PITRM1, and MSN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CERS5 grouped by Negative regulation of fat cell differentiation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CERS5 →	+0.481	+0.161	.006	.001	2	6
KIDNEY	PITRM1 →	+0.692	+0.235	.007	.002	3	4
STOMACH	MSN →	+4.353	+0.259	<.001	.001	3	4
LUNG_NSCLC_LUAD	CEACAM5 →	-2.564	-0.169	<.001	.003	3	3
LUNG_NSCLC_LUAD	STAG1 →	+0.531	+0.158	<.001	.002	3	3
LUNG_NSCLC_LUAD	GGACT →	-0.716	-0.133	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CERS5 by Negative regulation of fat cell differentiation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →