Negative regulation of fat cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMP1, AP3D1, and BTBD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of fat cell differentiation activity versus EMP1 in STOMACH (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	EMP1 →	-4.434	-0.933	<.001	.008	3	6
SKIN	AP3D1 →	+0.622	+0.756	.002	.004	3	5
OVARY	BTBD2 →	+0.828	+1.406	.009	<.001	3	5
BLOOD_Lymphoma	ALDH5A1 →	+2.117	+0.722	<.001	.001	3	5
BLOOD_Lymphoma	KDM4B →	+0.809	+0.975	.001	<.001	3	5
BONE	CTSZ →	-5.151	-1.637	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045599 vs EMP1 — STOMACH

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