Regulation of fat cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA11, RBMS1P1, and PDGFRB, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fat cell differentiation activity versus ITGA11 in CHOL (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	ITGA11 →	+1.704	+0.040	<.001	<.001	3	32
ESCA	RBMS1P1 →	+0.639	+0.064	<.001	<.001	3	32
THYM	PDGFRB →	+1.402	+0.038	<.001	<.001	3	31
TGCT	GLT8D2 →	+1.700	+0.020	<.001	<.001	3	31
MESO	ZFP36 →	+2.210	+0.026	<.001	<.001	3	31
KICH	THBS1 →	+2.302	+0.028	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045598 vs ITGA11 — CHOL

Explore this scatter interactively →