Regulation of fat cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of fat cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN1_S2162, ISLR, and PCOLCE, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fat cell differentiation activity versus TLN1_S2162 in LSCC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TLN1_S2162 →	+0.628	+0.031	<.001	<.001	3	10
OV	ISLR →	+0.880	+0.043	.002	<.001	3	10
OV	PCOLCE →	+0.837	+0.040	<.001	<.001	3	10
UCEC	AEBP1 →	+0.668	+0.059	<.001	<.001	3	10
UCEC	OLFML1 →	+0.930	+0.045	<.001	<.001	3	10
BRCA	RAI14 →	+0.400	+0.033	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045598 vs TLN1_S2162 — LSCC

Explore this scatter interactively →