Regulation of fat cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYL9, CNN1, and TPM2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fat cell differentiation activity versus MYL9 in COAD (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MYL9 →	+1.151	+0.520	<.001	.009	3	6
CCRCC	CNN1 →	+1.270	+0.511	.001	.001	2	7
BRCA	TPM2 →	+1.040	+0.837	<.001	<.001	3	6
BRCA	ASPN →	+1.581	+0.796	<.001	<.001	3	5
LSCC	CHL1 →	+1.253	+0.257	.002	.004	3	5
COAD	ABCA8 →	+0.987	+0.747	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045598 vs MYL9 — COAD

Explore this scatter interactively →