Regulation of fat cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMNA, ENTR1, and PRKACA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fat cell differentiation activity versus LMNA in SKIN (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LMNA →	-1.116	-0.895	.005	.006	3	5
OESOPHAGUS	ENTR1 →	-0.873	-1.107	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PRKACA →	-0.965	-1.501	<.001	.002	3	4
STOMACH	CDC42EP4 →	-1.162	-1.085	.004	.001	3	4
BLOOD_Myeloma	TTLL1 →	+1.075	+1.543	.002	<.001	3	4
SKIN	IL27RA →	-1.133	-0.871	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045598 vs LMNA — SKIN

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