Positive regulation of regulatory T cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of regulatory T cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SKAP2, WAS, and WDFY4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of regulatory T cell differentiation activity versus SKAP2 in OV (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SKAP2 →	+0.570	+0.038	<.001	.004	3	10
HNSC	WAS →	+0.503	+0.054	<.001	<.001	3	10
LSCC	WDFY4 →	+0.541	+0.073	<.001	<.001	3	10
GBM	APBB1IP →	+0.479	+0.057	<.001	<.001	3	10
HNSC	MYO1F →	+0.543	+0.086	<.001	<.001	3	10
LSCC	DOCK10 →	+0.513	+0.073	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045591 vs SKAP2 — OV

Explore this scatter interactively →