Positive regulation of regulatory T cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of regulatory T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL2A1, CSF3R, and VNN2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of regulatory T cell differentiation activity versus BCL2A1 in GBM (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BCL2A1 →	+1.295	+0.431	<.001	.004	3	7
LSCC	CSF3R →	+1.033	+0.297	<.001	.001	3	6
LSCC	VNN2 →	+0.730	+0.342	.002	<.001	3	6
COAD	PLEK →	+1.062	+0.580	<.001	<.001	3	6
GBM	NCF2 →	+0.766	+0.371	<.001	.002	3	6
BRCA	SLAMF6 →	+0.732	+0.558	.005	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045591 vs BCL2A1 — GBM

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