Negative regulation of regulatory T cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of regulatory T cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GBP5, LCP2, and TYMP, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of regulatory T cell differentiation activity versus GBP5 in GBM (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GBP5 →	+1.108	+0.087	<.001	.001	3	9
COAD	LCP2 →	+0.521	+0.066	<.001	.001	3	9
LSCC	TYMP →	+0.420	+0.062	<.001	<.001	3	8
BRCA	CASP1 →	+0.451	+0.081	<.001	<.001	3	8
BRCA	CASP4 →	+0.443	+0.105	<.001	<.001	3	8
HNSC	CD48 →	+0.775	+0.106	<.001	<.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045590 vs GBP5 — GBM

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