Negative regulation of regulatory T cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of regulatory T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZMYND19, IQGAP1, and MDK, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of regulatory T cell differentiation activity versus ZMYND19 in LUAD (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ZMYND19 →	+0.338	+0.479	.006	.004	3	3
LSCC	IQGAP1 →	-0.245	-0.564	.009	.001	3	3
OV	MDK →	+2.130	+0.104	<.001	.001	3	3
OV	CYP4Z2P →	-1.235	-0.074	.009	.001	3	3
OV	MIA3 →	-0.775	-0.076	.008	.001	3	3
OV	CARMIL1 →	-1.318	-0.123	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045590 vs ZMYND19 — LUAD

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