Negative regulation of regulatory T cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of regulatory T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIER2, DBNL, and FNIP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MIER2 grouped by Negative regulation of regulatory T cell differentiation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MIER2 →	+1.141	+0.162	<.001	.005	3	4
LIVER	DBNL →	+1.063	+0.370	.005	.009	3	4
BREAST	FNIP1 →	+0.553	+0.113	.001	.001	3	4
KIDNEY	ZNF518B →	-1.553	-0.209	.002	.004	3	4
UPPER_AERODIGESTIVE_TRACT	XKR6 →	+1.013	+0.312	.005	.007	3	4
BLOOD_Leukemia	PYCARD →	+1.638	+0.158	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MIER2 by Negative regulation of regulatory T cell differentiation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →