Negative regulation of regulatory T cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of regulatory T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOB1, PCBP1, and RAD51, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of regulatory T cell differentiation activity versus NOB1 in OVARY (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NOB1 →	+0.767	+0.343	.009	.006	2	7
LIVER	PCBP1 →	+0.839	+0.393	.001	.002	3	6
UPPER_AERODIGESTIVE_TRACT	RAD51 →	+0.824	+0.423	.003	.003	3	6
UPPER_AERODIGESTIVE_TRACT	WDR76 →	+1.210	+0.485	.001	.003	3	6
LARGE_INTESTINE	SCO1 →	+0.705	+0.300	.001	<.001	3	6
PANCREAS	CLUH →	+0.956	+0.426	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045590 vs NOB1 — OVARY

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