Positive regulation of gamma-delta T cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of gamma-delta T cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WIPF1, LUM, and RPL5, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of gamma-delta T cell differentiation activity versus WIPF1 in OV (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WIPF1 →	+0.491	+0.097	<.001	<.001	3	9
BRCA	LUM →	+0.735	+0.067	<.001	<.001	3	9
BRCA	RPL5 →	-0.190	-0.054	<.001	<.001	3	8
OV	SERBP1 →	-0.259	-0.069	.002	.006	3	8
GBM	STAB1 →	+0.515	+0.098	<.001	.001	3	8
GBM	TMEM119 →	+0.934	+0.115	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045588 vs WIPF1 — OV

Explore this scatter interactively →