Positive regulation of gamma-delta T cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of gamma-delta T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCF1C, NCF1, and SCIMP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of gamma-delta T cell differentiation activity versus NCF1C in GBM (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NCF1C →	+0.411	+0.230	.001	.006	3	5
LSCC	NCF1 →	+0.407	+0.524	<.001	.001	3	4
LSCC	SCIMP →	+0.454	+0.642	.007	.002	3	4
LSCC	USP30-AS1 →	+0.294	+0.464	<.001	.005	3	4
GBM	MILR1 →	+0.608	+0.299	.002	.002	3	4
CCRCC	UCP2 →	+0.643	+0.647	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045588 vs NCF1C — GBM

Explore this scatter interactively →