Positive regulation of gamma-delta T cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of gamma-delta T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFXN3, MYADM, and LIF, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SFXN3 grouped by Positive regulation of gamma-delta T cell differentiation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SFXN3 →	-2.849	-1.740	<.001	<.001	3	5
BONE	MYADM →	-2.220	-1.523	.005	<.001	3	5
BONE	LIF →	-4.137	-1.800	.001	<.001	3	4
BONE	WSB2 →	-1.384	-1.828	.002	<.001	3	4
BONE	SERTAD2 →	-1.627	-1.821	.004	<.001	1	6
LUNG_NSCLC_LUSC	MYO1C →	-1.578	-1.301	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SFXN3 by Positive regulation of gamma-delta T cell differentiation activity — BONE

Explore this box plot interactively →