Positive regulation of gamma-delta T cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of gamma-delta T cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX4I1, E2F5, and PIK3R1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COX4I1 grouped by Positive regulation of gamma-delta T cell differentiation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	COX4I1 →	+0.194	+0.255	.003	<.001	3	4
BREAST	E2F5 →	-0.297	-0.219	.001	.002	3	4
LARGE_INTESTINE	PIK3R1 →	-0.228	-0.252	.001	.001	3	4
PANCREAS	PUS7 →	+0.180	+0.274	<.001	<.001	3	3
SKIN	CFH →	-0.241	-0.164	.005	.001	3	3
KIDNEY	HACL1 →	-0.216	-1.353	.001	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COX4I1 by Positive regulation of gamma-delta T cell differentiation activity — BLOOD_Leukemia

Explore this box plot interactively →